This drug is an antibiotic used for cure of various bacterial infections in the body. The main ingredient of this drug is metronidazole. The company which manufactures and keeps of the copyrights for the brand-name Flagyl is Winthrop. The main ingredient metronidazole is manufactured under various brand names by different companies across the world.
What is the mechanism of action of metronidazole?
This drug is efficient to treat the infections which are caused by the bacteria and other class of Micro organelles is called protozoa. The metronidazole works by directly killing the bacteria. The active ingredient will enter into the bacterial cells and the cells of the protozoa could damage the DNA. The DNA of the genetic material is essential for multiplication and proliferation of the cells. With the damage to DNA these bacteria cannot grow and just get killed.
The medicine is more effective against anaerobic bacteria. This type of bacteria does not require oxygen to grow and multiply and as a result such bacteria cause infections of the bones, alimentary canal, pelvis and the gums. Apart from this the drug is indicated for the treatment of leg cells and pressure sores.
The drug is indicated for the treatment of infections post-surgery and in case of gynaecological surgeries. The drug can also penetrate the brain and thus it can treat brain abscesses as well.
And said before, the medicine can also be used for the treatment of infections caused by protozoa like trichomonas infection of vagina and amoebic dysentery. It can also be indicated as a part of triple therapy used in treatment of H. Pylori infection. It is combined with an antibiotic and a proton pump inhibitor for this purpose.
What are the cases in which this drug is indicated?
This medicine is indicated for
In which cases this medicine is contraindicated?
The drug was not being consumed if the patient has shown allergic to this drug before.
Use the medicine carefully in cases of hepatic encephalopathy, low liver function and diseases of brain and spinal cord.
Pregnancy and breastfeeding
The medicine has not been evaluated in pregnant women and hence, the safety of this drug is not known. Do not use this medicine in pregnancy at your own. The medicine can pass to the newborn baby through mother’s milk. Do not use this medicine if you are breastfeeding your child.
What are the side effects which may occur?
Like every other drug Flagyl has some side-effects. The side-effects of this antibiotic includes diarrhoea, nausea, vomiting, unpleasant taste, inflammation in mouth, skin rashes, loss of appetite and, depression, hallucinations, seizures and drowsiness.
What are the drug interactions?
One must avoid alcohol while taking this antibiotic for at least 48 hours after completing the course. Otherwise their chances to get unpleasant symptoms like abdominal cramps, nausea, vomiting and palpitations.
The antiblood clotting effect of warfarin may increase with this medicine. The blood levels of cyclosporine, lithium, and phenytoin can increase with the use of metronidazole. Medicine like phenobarbital can decrease the blood levels of metronidazole and make it less effective. Do not take oral typhoid vaccine within 72 hours after taking this drug.
This medicine can make the oral contraceptive pills less effective.