Kamagra contains sildenafil citrate as the active ingredient. The medicine is useful for the treatment of erectile dysfunction and it is indicated throughout the worldwide over 1 billion physicians for the treatment of this ailment. This medicine has been most selling drug throughout the world from past 2 decades.
How sildenafil will work?
Sildenafil citrate is a PDE 5 inhibitor drug. The PDE 5 is an enzyme found in males which is responsible for vasoconstriction after an erection is achieved. In short, this enzyme makes the penis flaccid.
There are various events which may occur when an erection is achieved. One of the important events is release of chemical substance called cyclic GMP. This cyclic GMP attaches itself to the muscular wall of arteries of penis and brings more blood into the specialised muscles of male organ called corpora cavernosa and corpora spongiosum. As a result of more blood and erection is achieved.
The PDE 5 does not allow appropriate amount of blood to flow into the penis and thus, it does not bring erection. To enhance the activity of cyclic GMP this medicine is consumed so that harder erections can be achieved.
What is this drug used for clinically?
This medicine is clinically indicated in impotence in men. It can also be indicated for the treatment of a rare pulmonary disorder called hypertension of the lungs. This disorder occurs in mountain climbers.
In which cases this drug cannot be used?
Sildenafil citrate cannot be used by women and children below 18 years of age. This drug can be consumed by patients taking nitrate medications also called as poppers. The drug is contraindicated in cases of severe blood pressure, stroke, heart attack and unstable angina. This drug can be consumed in cases of rare hereditary problems called galactose intolerance.
How this medicine is to be consumed?
The medicine is to be taken 30 minutes to 60 minutes before indulging into sexual activity. Take this medicine with plain water preferably on an empty stomach. Do not consume grapefruit juice with this drug and do not consume more than prescribed medicine in 24 hours.
What are the side effects?
A very common side effect of this medicine is headache. Common side effects are dizziness, flushing, indigestion and visual disturbances like blurred vision. Some uncommon side effects may occur which includes muscular pain, chest pain, dryness of mouth, skin rashes and eye disorders which includes bleeding in eyes and redness of eyes. Uncommon side effects also include angina, heart attack and stroke.
What are the drug interactions?
Like every medicine sildenafil citrate also interacts with other drugs. This medicine should not be combined with nitrate group of medicines which are also known as poppers like amyl nitrate. There can be a severe drop in blood pressure which can result into fainting or even heart attack when combined with nitrate medications. Blood pressure may also reduce the drug is combined with Alpha blockers like doxazosin.
Be careful when combining this medicine with other drugs like cimetidine, erythromycin and ketoconazole. The blood level of sildenafil citrate can increase significantly when taken with HIV protease inhibitor like ritonavir.